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In vivo studies demonstrate anatomically selective neurochemical results of modafinil on monoaminergic programs (de Saint Hilaire et al 2001; Ferraro et al 2002), and, notably, though modafinil increases TMN fos expression (Scammell et al 2000) and HAergic tone it truly is not able to exert this influence when administered directly in to the TMN (I

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